Which of the following is NOT metabolized by N-acetyltransferase 2?

Get ready for the Manor Preboards Module 3 Test. Enhance your skills with diverse multiple choice questions, detailed explanations, and insights. Ensure exam success!

Multiple Choice

Which of the following is NOT metabolized by N-acetyltransferase 2?

Explanation:
N-acetyltransferase 2 (NAT2) handles acetylation of certain drugs, and genetic differences create rapid or slow acetylators that change how much drug remains in the body. Classic NAT2 substrates include isoniazid, hydralazine, and procainamide. Acetaminophen, however, is not primarily processed by NAT2. Its main pathways are glucuronidation and sulfation, with a smaller portion oxidized by CYP enzymes to a toxic metabolite that is detoxified by glutathione. Because NAT2 doesn’t play a major role in acetaminophen metabolism, acetaminophen is the best answer as not being metabolized by NAT2.

N-acetyltransferase 2 (NAT2) handles acetylation of certain drugs, and genetic differences create rapid or slow acetylators that change how much drug remains in the body. Classic NAT2 substrates include isoniazid, hydralazine, and procainamide. Acetaminophen, however, is not primarily processed by NAT2. Its main pathways are glucuronidation and sulfation, with a smaller portion oxidized by CYP enzymes to a toxic metabolite that is detoxified by glutathione. Because NAT2 doesn’t play a major role in acetaminophen metabolism, acetaminophen is the best answer as not being metabolized by NAT2.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy