Which drug is known to produce a disulfiram-like reaction when taken with alcohol?

• A. Metronidazole
• B. Amlodipine
• C. Ibuprofen
• D. Acetaminophen

Answer: (A)

A drug-alcohol interaction that causes a disulfiram-like reaction occurs when the medicine blocks aldehyde dehydrogenase, so acetaldehyde builds up after drinking alcohol and triggers symptoms like flushing, palpitations, nausea, and vomiting. Metronidazole is a well-known example of a medication that can produce this reaction with alcohol. If alcohol is consumed during metronidazole therapy, you may experience those unpleasant symptoms from the acetaldehyde buildup. The other drugs listed don’t produce this specific reaction: amlodipine doesn’t cause the disulfiram-like effect, ibuprofen isn’t associated with it, and acetaminophen with alcohol increases liver toxicity risk but not this acetaldehyde accumulation mechanism. So metronidazole is the drug known for this interaction.