What type of necrosis is most commonly associated with ischemic injury in solid organs?

• A. Liquefactive necrosis
• B. Caseous necrosis
• C. Coagulative necrosis
• D. Fat necrosis

Answer: (C)

Ischemic injury in solid organs mainly produces coagulative necrosis. When blood flow is interrupted, cells face oxygen deprivation and ATP depletion. This leads to protein denaturation that preserves the structural outline of the tissue for a time, so the dead cells form a “ghost-like” framework while the nuclei disappear. This pattern is typical of infarcts in solid organs such as the heart, kidney, and spleen. Other types of necrosis are more characteristic of different contexts: liquefactive necrosis occurs more with brain tissue after ischemia, caseous necrosis is associated with granulomatous infections like tuberculosis, and fat necrosis occurs in adipose tissue during pancreatitis or trauma.